Malignant mesothelioma (MM) is poorly responsive to systemic cytotoxic chemotherapy and invariably fatal.Here we describe a screen of 94 drugs in 15 exome-sequenced MM lines and the discovery of a subset defined by loss of function of the nuclear deubiquitinase BRCA associated protein-1 (BAP1) that demonstrate heightened sensitivity to TRAIL (tumou
Penetrating injuries to the chest are among the most common injuries seen in the casualty department at Hillbrow Hospital, Johannesburg.Opinions regarding the surgical handling of patients with penetrating chest trauma continue to differ.The purpose of this study was to STOOL determine whether there would be a difference in outcome in patients who
Hepatitis C virus (HCV) infection Cocktail Set is considered a major health problem recognized globally.HCV is a major cause of chronic liver disease that may lead to cirrhosis and hepatocellular carcinoma.The aim of this study was to investigate the prevalence of multiple (mixed) HCV genotypes in Saudi patients recently diagnosed with HCV infectio